by Peter James | Feb 12, 2025 | Health
Ivermectin, a widely used antiparasitic drug, has gained attention in recent years for its potential to be repurposed in cancer treatment. Originally developed to combat parasitic infections in both humans and in animals. The use of ivermectin outside of its original intention has demonstrated anticancer properties in early pre-clinical studies. While it has not yet been approved for cancer treatment, there is emerging research suggesting that it could really complement existing therapies and provide an alternative approach for certain types of cancer. The Mechanism of Ivermectin in Cancer Therapy Ivermectin appears to exert anticancer effects through multiple mechanisms, including: Inducing Apoptosis (Programmed Cell Death): Studies suggest that ivermectin can trigger apoptosis in cancer cells by inhibiting key survival pathways. Inhibiting Cancer Cell Proliferation: Research has shown that ivermectin interferes with cancer cell growth by disrupting various signaling pathways, such as the WNT/β-catenin and Hippo pathways, which are involved in tumor progression. Targeting Cancer Stem Cells: Cancer stem cells contribute to tumor growth and resistance to treatment. Ivermectin has been shown to reduce the viability of these cells, making it a promising candidate for preventing cancer recurrence. Enhancing Chemosensitivity: Some studies suggest that ivermectin can enhance the effectiveness of chemotherapy drugs by overcoming drug resistance mechanisms. Potential Applications for Different Cancer Types Preclinical studies have explored ivermectin’s effects on various cancers, including: Breast Cancer: Research indicates that ivermectin can inhibit breast cancer cell growth and enhance sensitivity to chemotherapy. Lung Cancer: Studies suggest that ivermectin may suppress lung cancer progression by modulating key signaling pathways. Colorectal Cancer: Ivermectin has been shown to reduce the viability of colorectal cancer cells and enhance the effects of other anticancer agents....
by Peter James | Feb 4, 2025 | Fitness, Health
When designing a weightlifting program, it’s important to align your training with your specific goals. Depending upon your lifestyle outside of the gym you may want to train more specifically. For example if you want to build muscle and look stronger it’s essential to work with a free weight routine that will help allow you to live the life that you want and desire. For some once they build muscle definition they want to stay and maintain being in generally good shape. Others want to be more fit for a specific sport and do various competitions where it is a more vigorous and time consuming sports specific training. Ultimately the type of body you want to build and why you want to exercise will help define what type of fitness routine is best for you. Power, strength, and endurance training each have their own unique benefits, require different rep and set schemes, and target distinct physiological adaptations. In this post, I’ll break down the key differences between these training styles and help you decide ultimately which one or combination is the best for you. Power Training Goal: Explosive Force Production Power training focuses on generating maximum force in the shortest possible time frame. For those who want to be very powerful and forceful in their bodies ability to move weight this type of training can suit those with a more natural larger build and those with the genetic gift of bigger bones. It is essential for athletes in sports that require quick, explosive movements, such as basketball, football, soccer, sprinting, and Olympic weightlifting. Key Characteristics: Load: 50–90% of 1-rep max (1RM)...
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